Blood Lipid Profile in Long-Tailed Monkeys (Macaca fascicularis) Induced High-Fat Diets

Abstract: High-energy diets with sources of fat can encourage the development of obesity which is usually accompanied by changes in blood lipid profiles. The aim of this study was to evaluate the effect of a high-energy diet with sources of animal fat and egg yolk as an obese diet on the lipid profile of blood of long-tailed monkeys (Macaca fascicularis) given for four months. Fifteen adult male monkeys were divided into three diet groups randomly into groups 1) high fat from animal fat without egg yolk, or 2) high fat with egg yolk, (19.62% fat on both diets), or 3) diet monkey chow standard as a control (5.55% fat). Measurements were made every month for body weight, blood lipid profiles such as cholesterol, triglycerides, high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C), and at the end of the study, fat consumption and digestibility were evaluated. The results showed that animals with high fat consumption with egg yolk increased body weight significantly at 4 and 8 weeks (p <0.05) and at 16 weeks, total plasma cholesterol and LDL-C increased significantly compared to the other two groups. . However, triglycerides and HDL, do not differ in all three groups. Fat consumption for each month was significantly increased in animals who received a diet plus egg yolk, but fat digestibility was the same in all groups. Based on these results, diets containing high fat with egg yolk increase palatability, body weight and plasma total cholesterol, so that it has the potential to be developed by models of obesity models accompanied by an increase in blood profile as one of the metabolic syndromes.

Abstract: Diet with high energy from high fat promotes the development of obesity usually accompanied by blood lipid alteration. The objective of this research is to evaluate the effect of high energy diet with high fat and high egg diet on blood lipid profiles of cynomolgus monkeys (Macaca fascicularis) given for four months. Fifteen adult males is divided into three groups of diet 1) high fat from beff tallow without egg yolk; or 2) high fat from tallow and egg yolk, (fat 19.62% in both diets), or 3) monkey chow as control (5.55% fat). Measurements were carried out every month for body weight, blood lipid profiles such as cholesterol, triglyceride, high density lipoprotein (HDl-C) and cholesterol low density lipoprotein (LDL-C), and the study of fat consumption and digestibility were evaluated . Results showed animals increased body weight at week-4 and 8 (p <0.05) and increased the total cholesterol plasma and LDL at the end of study. However, Triglyceride and HDL, were not different in all three groups. Fat consumption is significantly increased in accepting tallow and egg yolk, however the fat digestibility was equal in all groups. Based on this result, diet containing high fat with egg yolk increased palatability, body weight and total plasma cholesterol, therefore it has a potential blood model with an increased blood lipid profile as one of the symptoms of metabolic syndrome.

Key words: obesity, cynomolgus, beef tallow, egg yolk, total plasma cholesterol