Poor Memory Performance in Aged Cynomolgus Monkeys with Hippocampal Atrophy, Depletion of Amyloid Beta 1-42 and Accumulation of Tau Proteins in Cerebrospinal FluidAuthor: HUDA S. DARUSMAN, JACUB PANDELAKI, RAHMAD MULYADI, DONDIN SAJUTHI, INDAH A. PUTRI, OTTO H. KALLIOKOSI, JOSEP CALL, KLAS S.P. ABELSON, STEVEN J. SCHAPIRO, ALBERT GJEDDE, and JANN HAU
Background: Due to their similarities in behavior and disease pathology to humans, non-human primate model are desirable to complement small animals as models for the study of age-related dementia. Materials and Methods: Based on their performance on delayed response task (DRT) test of memory, aged cynomolgus monkeys were divide into two groups compare high-perfroming (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers realted to Alzhemeir’s disease and their brains were scanned using structural magnetic resonance imaging. Results: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p<0.001) and higher cerebrospinal fluid total tau levels (p<0.05) compared with the group performing well on the DRT tests. Conclusion: These findings suggest that old, memory-impaired
Keywords: Neurodegenerative disease, non-human primate, memory, biomarkers, magnetic resonance imaging.