Profil Lipid Darah pada Monyet Ekor Panjang (Macaca fascicularis) yang Diinduksi Diet Tinggi Lemak
Abstract: Diet with high energy from high fat promotes the development of obesity which usually accompanied by blood lipid alteration. The objective of this research was to evaluate the effect of high energy diet with high fat from tallow and egg yolk as obese diet on blood lipid profile of cynomolgus monkeys (Macaca fascicularis) given for four months. Fifteen adult males divided equally into three groups of diet 1) high fat from beff tallow without egg yolk; or 2) high fat from tallow and egg yolk, (fat 19.62% in both diets), or 3) monkey chow as control (fat 5.55%). Measurements were carried out every month for body weight, blood lipid profile such as cholesterol, triglyceride, high density lipoprotein (HDl-C) and low density lipoprotein cholesterol ( LDL-C), and at the end of study fat consumption and digestibility were evaluated. Results showed animals consumed high fat with egg yolk increased significantly in their body weight at week-4 and 8 (p<0.05) and concurrently an increased of the total plasma cholesterol and LDL at the end of study. However, triglyceride and HDL, was not different in all three groups. Fat consumption for each month was significantly increased in animals receiving tallow and egg yolk, however the fat digestibility was equal in all groups. Based on this result, diet containing high fat with egg yolk increased palatability, body weight and total plasma cholesterol, therefore it has potential to developed obese animal model with increased blood lipid profile as one symptoms of metabolic syndrome.
Key words: obesity, cynomolgus, beef tallow, egg yolk, total plasma cholesterol