Macaca nemestrina and Dengue Virus Infectivity:a Potential Model for Evaluating Dengue Vaccine Candidates
Author: SUSANA WIDJAJA , IMELDA, JONATHAN, CHAIRIN N MAROEF, ERLIN LlSTlYANINGSIH, RATNA TAN, JOKO PAMUNGKAS, DIAH ISKANDRIATI, PATRICK J BLAIR, DONDIN SAJUTHI, RANDALL PORTER
Abstract
Macaca nemestrina has been shown to respond to infectious disease agents, such as HIV, and is more sensitive compared to other species of macaques such as rhesus (M. mulatta) andcynomolgus monkeys (M fascicularis). To evaluate M. nemestrina for the ability to support dengue (DEN) viremia and serve potentially as an improved model for testing DEN vaccines, a series of experiments were conducted using primary viral isolates from individuals with DEN virus infections. This study shows that M. nemestrina develops consistent, measurable viremia with all four DEN serotypesand produces immune responses sufficient to protect against homologous virus. Anti-dengue antibodies generated afier infection are predominately IgGI. This species of monkey therefore appears to be a suitable model for testing DEN virus vaccine candidates.
